Ontology highlight
ABSTRACT:
SUBMITTER: Pearson JR
PROVIDER: S-EPMC4725958 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Pearson John R JR Zurita Federico F Tomás-Gallardo Laura L Díaz-Torres Alfonsa A Díaz de la Loza María Del Carmen Mdel C Franze Kristian K Martín-Bermudo María D MD González-Reyes Acaimo A
PLoS genetics 20160125 1
The extracellular matrix (ECM) is a pivotal component adult tissues and of many tissue-specific stem cell niches. It provides structural support and regulates niche signaling during tissue maintenance and regeneration. In many tissues, ECM remodeling depends on the regulation of MMP (matrix metalloproteinase) activity by inhibitory TIMP (tissue inhibitors of metalloproteinases) proteins. Here, we report that the only Drosophila timp gene is required for maintaining the normal organization and fu ...[more]