Ontology highlight
ABSTRACT:
SUBMITTER: Brune KD
PROVIDER: S-EPMC4725971 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Brune Karl D KD Leneghan Darren B DB Brian Iona J IJ Ishizuka Andrew S AS Bachmann Martin F MF Draper Simon J SJ Biswas Sumi S Howarth Mark M
Scientific reports 20160119
Virus-like particles (VLPs) are non-infectious self-assembling nanoparticles, useful in medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive for engineering multivalency, notably for vaccination. However, decorating VLPs with target-antigens by genetic fusion or chemical modification is time-consuming and often leads to capsid misassembly or antigen misfolding, hindering generation of protective immunity. Here we establish a platform for irreversibly decor ...[more]