Enhancement of human sodium iodide symporter gene therapy for breast cancer by HDAC inhibitor mediated transcriptional modulation.
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ABSTRACT:
SUBMITTER: Kelkar MG
PROVIDER: S-EPMC4726020 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Enhancement of human sodium iodide symporter gene therapy for breast cancer by HDAC inhibitor mediated transcriptional modulation.
Kelkar Madhura G MG Senthilkumar Kalimuthu K Jadhav Smita S Gupta Sudeep S Ahn Beyong-Cheol BC De Abhijit A
Scientific reports 20160118
The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase reporter based initial screening of six different HDACi shows 2-10 fold enhancement of NIS promoter activity in majority of the cell types tested. As a result of drug treatment, endogenous NIS transcrip ...[more]
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