Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples.
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ABSTRACT:
SUBMITTER: Bispo VS
PROVIDER: S-EPMC4726056 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples.
Bispo Vanderson S VS de Arruda Campos Ivan P IP Di Mascio Paolo P Medeiros Marisa H G MH
Scientific reports 20160119
Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensive spectroscopic measurements. The adduct with urinary concentrations of 1.82 ± 0.68 nmol/mg of creatinine is one of the most abundant acrolein metabolites in urine and opens promising therapeutic stra ...[more]
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