Ontology highlight
ABSTRACT:
SUBMITTER: Kim AR
PROVIDER: S-EPMC4726293 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kim A-Ram AR Kim Hyuk Soon HS Kim Do Kyun DK Nam Seung Taek ST Kim Hyun Woo HW Park Young Hwan YH Lee Dajeong D Lee Min Bum MB Lee Jun Ho JH Kim Bokyung B Beaven Michael A MA Kim Hyung Sik HS Kim Young Mi YM Choi Wahn Soo WS
Scientific reports 20160120
Food allergy is a hypersensitive immune reaction to food proteins. We have previously demonstrated the presence of IL-10-producing CD5(+) B cells and suggested their potential role in regulating cow's milk casein allergy in humans and IgE-mediated anaphylaxis in mice. In this study, we determined whether IL-10-producing CD5(+) regulatory B cells control casein-induced food allergic responses in mice and, if so, the underlying mechanisms. The induction of oral tolerance (OT) by casein suppressed ...[more]