Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TT
PROVIDER: S-EPMC4726371 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nguyen Thi Thuy Trang TT Chua Jacqueline Kia Kee JK Seah Kwi Shan KS Koo Seok Hwee SH Yee Jie Yin JY Yang Eugene Guorong EG Lim Kim Kiat KK Pang Shermaine Yu Wen SY Yuen Audrey A Zhang Louxin L Ang Wee Han WH Dymock Brian B Lee Edmund Jon Deoon EJ Chen Ee Sin ES
Scientific reports 20160121
Contemporary chemotherapeutic treatments incorporate the use of several agents in combination. However, selecting the most appropriate drugs for such therapy is not necessarily an easy or straightforward task. Here, we describe a targeted approach that can facilitate the reliable selection of chemotherapeutic drug combinations through the interrogation of drug-resistance gene networks. Our method employed single-cell eukaryote fission yeast (Schizosaccharomyces pombe) as a model of proliferating ...[more]