Ontology highlight
ABSTRACT:
SUBMITTER: Kim KH
PROVIDER: S-EPMC4726432 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kim Kyoung-Han KH Rosen Anna A Hussein Samer M I SM Puviindran Vijitha V Korogyi Adam S AS Chiarello Carmelina C Nagy Andras A Hui Chi-Chung CC Backx Peter H PH
Scientific reports 20160120
The ventricular conduction system (VCS) orchestrates the harmonious contraction in every heartbeat. Defects in the VCS are often associated with life-threatening arrhythmias and also promote adverse remodeling in heart disease. We have previously established that the Irx3 homeobox gene regulates rapid electrical propagation in the VCS by modulating the transcription of gap junction proteins Cx40 and Cx43. However, it is unknown whether other factors contribute to the conduction defects observed ...[more]