Ontology highlight
ABSTRACT:
SUBMITTER: Fukumoto J
PROVIDER: S-EPMC4726536 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Fukumoto Jutaro J Cox Ruan R Fukumoto Itsuko I Cho Young Y Parthasarathy Prasanna Tamarapu PT Galam Lakshmi L Lockey Richard F RF Kolliputi Narasaiah N
PloS one 20160125 1
Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPK kinase kinase kinase (MAP3K) family, is activated by various stimuli, which include oxidative stress, endoplasmic reticulum (ER) stress, calcium influx, DNA damage-inducing agents and receptor-mediated signaling through tumor necrosis factor receptor (TNFR). Inspiration of a high concentration of oxygen is a palliative therapy which counteracts hypoxemia caused by acute lung injury (ALI)-induced pulmonary edema. However, animal ex ...[more]