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The mitogenome of Onchocerca volvulus from the Brazilian Amazonia focus.

ABSTRACT: We report here the first complete mitochondria genome of Onchocerca volvulus from a focus outside of Africa. An O. volvulus mitogenome from the Brazilian Amazonia focus was obtained using a combination of high-throughput and Sanger sequencing technologies. Comparisons made between this mitochondrial genome and publicly available mitochondrial sequences identified 46 variant nucleotide positions and suggested that our Brazilian mitogenome is more closely related to Cameroon-origin mitochondria than West African-origin mitochondria. As well as providing insights into the origins of Latin American onchocerciasis, the Brazilian Amazonia focus mitogenome may also have value as an epidemiological resource.

SUBMITTER: Crainey JL

PROVIDER: S-EPMC4727440 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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The mitogenome of Onchocerca volvulus from the Brazilian Amazonia focus.

Crainey James L JL Silva Túllio R R da TR Encinas Fernando F Marín Michel A MA Vicente Ana Carolina P AC Luz Sérgio L B SL

Memorias do Instituto Oswaldo Cruz 20160101 1

We report here the first complete mitochondria genome of Onchocerca volvulus from a focus outside of Africa. An O. volvulus mitogenome from the Brazilian Amazonia focus was obtained using a combination of high-throughput and Sanger sequencing technologies. Comparisons made between this mitochondrial genome and publicly available mitochondrial sequences identified 46 variant nucleotide positions and suggested that our Brazilian mitogenome is more closely related to Cameroon-origin mitochondria th ...[more]

PMID: 26814648

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