Ontology highlight
ABSTRACT:
SUBMITTER: Zilbermint M
PROVIDER: S-EPMC4727445 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Zilbermint Mihail M Ramnitz Mary S MS Lodish Maya B MB Kanaka-Gantenbein Christina C Kattamis Antonis A Lyssikatos Charalampos C Patronas Nicholas J NJ Quezado Martha M MM Stratakis Constantine A CA
Journal of pediatric endocrinology & metabolism : JPEM 20140301 3-4
Germinomas presenting with a pituitary stalk lesion and panhypopituitarism are rare in children, and their definite diagnosis is challenging. An invasive diagnostic approach, such as a transsphenoidal biopsy, is often required prior to establishing a treatment regimen. A 13-year-old female presented with 1 year of secondary amenorrhea, fatigue, and progressive thirst with polyuria. Laboratory work-up revealed panhypopituitarism (central hypothyroidism, hypogonadotropic hypogonadism, adrenal insu ...[more]