Ontology highlight
ABSTRACT:
SUBMITTER: Scalvini L
PROVIDER: S-EPMC4728057 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chemistry and physics of lipids 20150726
Monoglyceride lipase (MGL), the main enzyme responsible for the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG), is an intracellular serine hydrolase that plays critical roles in many physiological and pathological processes, such as pain, inflammation, neuroprotection and cancer. The crystal structures of MGL that are currently available provide valuable information about how this enzyme might function and interact with site-directed small-molecule inhibitors. O ...[more]