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Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif.

ABSTRACT: BRCA1 BRCT domains function as phosphoprotein-binding modules for recognition of the phosphorylated protein-sequence motif pSXXF. While the motif interaction interface provides strong anchor points for binding, protein regions outside the motif have recently been found to be important for binding affinity. In this review, we compare the available structural data for BRCA1 BRCT domains in complex with phosphopeptides in order to gain a more complete understanding of the interaction between phosphopeptides and BRCA1-BRCT domains.

SUBMITTER: Wu Q

PROVIDER: S-EPMC4728184 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif.

Wu Qian Q Jubb Harry H Blundell Tom L TL

Progress in biophysics and molecular biology 20150217 2-3

BRCA1 BRCT domains function as phosphoprotein-binding modules for recognition of the phosphorylated protein-sequence motif pSXXF. While the motif interaction interface provides strong anchor points for binding, protein regions outside the motif have recently been found to be important for binding affinity. In this review, we compare the available structural data for BRCA1 BRCT domains in complex with phosphopeptides in order to gain a more complete understanding of the interaction between phosph ...[more]

PMID: 25701377

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