Ontology highlight
ABSTRACT:
SUBMITTER: Fischer G
PROVIDER: S-EPMC4728186 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Current opinion in biotechnology 20150515
Protein-protein interactions (PPI) have become increasingly popular drug targets, with a number of promising compounds currently in clinical trials. Recent research shows, that PPIs can be modulated in more ways than direct inhibition, where novel non-competitive modes of action promise a solution for the difficult nature of PPI drug discovery. Here, we review recently discovered PPI modulators in light of their mode of action and categorise them as disrupting versus stabilising, orthosteric ver ...[more]