Ontology highlight
ABSTRACT:
SUBMITTER: Juhling F
PROVIDER: S-EPMC4728377 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Jühling Frank F Kretzmer Helene H Bernhart Stephan H SH Otto Christian C Stadler Peter F PF Hoffmann Steve S
Genome research 20151202 2
The detection of differentially methylated regions (DMRs) is a necessary prerequisite for characterizing different epigenetic states. We present a novel program, metilene, to identify DMRs within whole-genome and targeted data with unrivaled specificity and sensitivity. A binary segmentation algorithm combined with a two-dimensional statistical test allows the detection of DMRs in large methylation experiments with multiple groups of samples in minutes rather than days using off-the-shelf hardwa ...[more]