Ontology highlight
ABSTRACT:
SUBMITTER: Berry DC
PROVIDER: S-EPMC4728429 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Berry Daniel C DC Jiang Yuwei Y Graff Jonathan M JM
Nature communications 20160105
Cold temperatures induce formation of beige adipocytes, which convert glucose and fatty acids to heat, and may increase energy expenditure, reduce adiposity and lower blood glucose. This therapeutic potential is unrealized, hindered by a dearth of genetic tools to fate map, track and manipulate beige progenitors and 'beiging'. Here we examined 12 Cre/inducible Cre mouse strains that mark adipocyte, muscle and mural lineages, three proposed beige origins. Among these mouse strains, only those tha ...[more]