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Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria.


ABSTRACT: Anabaenopeptins, bioactive cyclic hexapeptides, were isolated by preparative reversed-phase high performance liquid chromatography from an extract of Baltic Sea cyanobacterial bloom material composed of Nodularia spumigena (50%), Aphanizomenon flos-aquae (40%) and Dolichospermum spp. (10%). Five new anabaenopeptins and nine previously known anabaenopeptins were isolated, and their putative structures were determined by tandem mass spectrometry. The activity of the peptides against carboxypeptidase A and protein phosphatase 1 as well as chymotrypsin, trypsin and thrombin was tested. All anabaenopeptins inhibited carboxypeptidase A (apart from one anabaenopeptin variant) and protein phosphatase 1 with varying potency, but no inhibition against chymotrypsin, trypsin and thrombin was observed.

SUBMITTER: Spoof L 

PROVIDER: S-EPMC4728505 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria.

Spoof Lisa L   Błaszczyk Agata A   Meriluoto Jussi J   Cegłowska Marta M   Mazur-Marzec Hanna H  

Marine drugs 20151230 1


Anabaenopeptins, bioactive cyclic hexapeptides, were isolated by preparative reversed-phase high performance liquid chromatography from an extract of Baltic Sea cyanobacterial bloom material composed of Nodularia spumigena (50%), Aphanizomenon flos-aquae (40%) and Dolichospermum spp. (10%). Five new anabaenopeptins and nine previously known anabaenopeptins were isolated, and their putative structures were determined by tandem mass spectrometry. The activity of the peptides against carboxypeptida  ...[more]

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