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Stimuli-responsive supramolecular hydrogels with high extensibility and fast self-healing via precoordinated mussel-inspired chemistry.

ABSTRACT: Supramolecular hydrogels have the advantages of stimuli responsiveness and self-healing compared to covalently crosslinked hydrogels. However, the existing supramolecular hydrogels are usually poor in mechanical properties especially in extensibility. In addition, these supramolecular hydrogels need a long self-healing time and have low self-healing efficiency. In this manuscript, we report a novel strategy to develop highly extensible and fast self-healing supramolecular hydrogels by using pre-coordinated mussel-inspired catechol-Fe3+ complexes as dynamic crosslinkers. The hydrogel can be fabricated and cast into various shapes by one-step photo-crosslinking. Thus fabricated hydrogels can be stretched beyond 10 times their original lengths, and the high extensibility can completely recover within a very short time (less than 20 minutes) even after the hydrogels are entirely cut apart. Utilizing the dynamic nature of supramolecular hydrogels, we can realize different mechanical behaviors including strength, extensibility and recoverability by varying the loading conditions. In addition, the hydrogels respond to multiple stimuli including mechanical force, temperature and certain chemicals because of the dynamic catechol-Fe3+ bond.

SUBMITTER: Hou S

PROVIDER: S-EPMC4729395 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Stimuli-responsive supramolecular hydrogels with high extensibility and fast self-healing via precoordinated mussel-inspired chemistry.

Hou Sen S Ma Peter X PX

Chemistry of materials : a publication of the American Chemical Society 20151027 22

Supramolecular hydrogels have the advantages of stimuli responsiveness and self-healing compared to covalently crosslinked hydrogels. However, the existing supramolecular hydrogels are usually poor in mechanical properties especially in extensibility. In addition, these supramolecular hydrogels need a long self-healing time and have low self-healing efficiency. In this manuscript, we report a novel strategy to develop highly extensible and fast self-healing supramolecular hydrogels by using pre- ...[more]

PMID: 26834315

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Project description:The combination of multiple physiological (swelling, porosity, mechanical, and biodegradation) and biological (cell/tissue-adhesive, cell proliferation, and hemostatic) properties on a single hydrogel has great potential for skin tissue engineering. Adhesive hydrogels based on polydopamine (PDA) have become the most popular in the biomedical field; however, integrating multiple properties on a single adhesive hydrogel remains a challenge. Here, inspired by the chemistry of mussels, we developed PDA-sodium alginate-polyacrylamide (PDA-SA-PAM)-based hydrogels with multiple physiological and biological properties for skin tissue engineering applications. The hydrogels were prepared by alkali-induced polymerization of DA followed by complexation with SA in PAM networks. The chemical composition of the hydrogels was characterized by X-ray photoelectron spectroscopy. PDA-SA complexed chains were homogeneously dispersed in the PAM network and exhibited good elasticity and excellent mechanical properties, such as a compressive stress of 0.24 MPa at a compression strain of 70% for 0.4PDA-SA-PAM. The adhesive hydrogel also maintained a highly interconnected porous structure (∼94% porosity) along with PDA microfibrils. The hydrogel possesses outstanding swelling and biodegradability properties. Owing to the presence of the PDA-SA complex in the PAM network, the hydrogels show good adhesion to various substrates (plastic, skin, glass, computer screens, and leaves); for example, the adhesive strength of the 0.4PDA-SA-PAM to porcine skin was 24.5 kPa. The adhesive component of the PDA-SA chains in the PAM network significantly improves the cell proliferation, cell attachment, cell spreading, and functional expression of human skin fibroblasts (CCD-986sk) and keratinocytes. Moreover, the PDA chains exhibited good hemostatic properties, resulting in rapid blood coagulation. Considering their excellent cell affinity, and rapid blood coagulation ability, these mussel-inspired hydrogels have substantial potential for skin tissue engineering applications.

Dataset Information

Stimuli-responsive supramolecular hydrogels with high extensibility and fast self-healing via precoordinated mussel-inspired chemistry.

Publications

Stimuli-responsive supramolecular hydrogels with high extensibility and fast self-healing via precoordinated mussel-inspired chemistry.

Similar Datasets

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