Ontology highlight
ABSTRACT:
SUBMITTER: Bluestone JA
PROVIDER: S-EPMC4729454 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Bluestone Jeffrey A JA Buckner Jane H JH Fitch Mark M Gitelman Stephen E SE Gupta Shipra S Hellerstein Marc K MK Herold Kevan C KC Lares Angela A Lee Michael R MR Li Kelvin K Liu Weihong W Long S Alice SA Masiello Lisa M LM Nguyen Vinh V Putnam Amy L AL Rieck Mary M Sayre Peter H PH Tang Qizhi Q
Science translational medicine 20151101 315
Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune disease setting. Thus, efforts to repair or replace Tregs in T1D may reverse autoimmunity and protect the remaining insulin-producing β cells. On the basis of this premise, a robust technique has been developed to isolate and expand Tregs from patients with T1D. The expanded Tregs retained their T cell receptor diversity a ...[more]