Ontology highlight
ABSTRACT:
SUBMITTER: Matza D
PROVIDER: S-EPMC4729531 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Matza Didi D Badou Abdallah A Klemic Kathryn G KG Stein Judith J Govindarajulu Usha U Nadler Monica J MJ Kinet Jean-Pierre JP Peled Amnon A Shapira Oz M OM Kaczmarek Leonard K LK Flavell Richard A RA
PloS one 20160127 1
The process of calcium entry in T cells is a multichannel and multi-step process. We have studied the requirement for L-type calcium channels (Cav1.1) α1S subunits during calcium entry after TCR stimulation. High expression levels of Cav1.1 channels were detected in activated T cells. Sequencing and cloning of Cav1.1 channel cDNA from T cells revealed that a single splice variant is expressed. This variant lacks exon 29, which encodes the linker region adjacent to the voltage sensor, but contain ...[more]