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Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.

ABSTRACT: Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

SUBMITTER: Daniel KB 

PROVIDER: S-EPMC4729588 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.

Daniel Kevin B KB   Callmann Cassandra E CE   Gianneschi Nathan C NC   Cohen Seth M SM  

Chemical communications (Cambridge, England) 20160201 10

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS. ...[more]

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