Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC4729596 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Liu Xu X Mao Kai K Yu Angela Y H AYH Omairi-Nasser Amin A Austin Jotham J Glick Benjamin S BS Yip Calvin K CK Klionsky Daniel J DJ
Current biology : CB 20160107 2
Macroautophagy (hereafter autophagy) is an evolutionarily conserved process in which portions of the cytoplasm are engulfed, degraded, and subsequently recycled. The Atg17-Atg31-Atg29 complex translocates to the phagophore assembly site (PAS), where an autophagosome forms, at a very early stage of autophagy, playing a vital role in autophagy induction. Here, we identified a novel role of this complex in a late stage of autophagy where it coordinates with Atg11 to regulate autophagy-specific fusi ...[more]