Ontology highlight
ABSTRACT:
SUBMITTER: Laurent V
PROVIDER: S-EPMC4729927 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Laurent Victor V Guérard Adrien A Mazerolles Catherine C Le Gonidec Sophie S Toulet Aurélie A Nieto Laurence L Zaidi Falek F Majed Bilal B Garandeau David D Socrier Youri Y Golzio Muriel M Cadoudal Thomas T Chaoui Karima K Dray Cedric C Monsarrat Bernard B Schiltz Odile O Wang Yuan Yuan YY Couderc Bettina B Valet Philippe P Malavaud Bernard B Muller Catherine C
Nature communications 20160112
Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In ...[more]