Ontology highlight
ABSTRACT:
SUBMITTER: Abbey M
PROVIDER: S-EPMC4730212 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Abbey Megha M Hakim Cosima C Anand Roopsee R Lafera Juri J Schambach Axel A Kispert Andreas A Taft Manuel H MH Kaever Volkhard V Kotlyarov Alexey A Gaestel Matthias M Menon Manoj B MB
Scientific reports 20160128
Septin 7 (SEPT7) has been described to be essential for successful completion of cytokinesis in mouse fibroblasts, and Sept7-deficiency in fibroblasts constitutively results in multinucleated cells which stop proliferation. Using Sept7(flox/flox)fibroblasts we generated a cellular system, where the cytokinetic defects of Cre-mediated deletion of the Sept7 gene can be rescued by ectopically expressed doxycycline-inducible wild type SEPT7. Using this system, we analyzed the ability of SEPT7-mutant ...[more]