In Silico Insight into Potential Anti-Alzheimer's Disease Mechanisms of Icariin.
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ABSTRACT:
SUBMITTER: Cui Z
PROVIDER: S-EPMC4730354 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
In Silico Insight into Potential Anti-Alzheimer's Disease Mechanisms of Icariin.
Cui Zhijie Z Sheng Zhen Z Yan Xinmiao X Cao Zhiwei Z Tang Kailin K
International journal of molecular sciences 20160115 1
Herbal compounds that have notable therapeutic effect upon Alzheimer's disease (AD) have frequently been found, despite the recent failure of late-stage clinical drugs. Icariin, which is isolated from Epimedium brevicornum, is widely reported to exhibit significant anti-AD effects in in vitro and in vivo studies. However, the molecular mechanism remains thus far unclear. In this work, the anti-AD mechanisms of icariin were investigated at a target network level assisted by an in silico target id ...[more]
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