Ontology highlight
ABSTRACT:
SUBMITTER: Conrad TA
PROVIDER: S-EPMC4730586 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Conrad Turner Allen TA Gong Siqi S Yang Zhangsheng Z Matulich Patrick P Keck Jonathon J Beltrami Noah N Chen Chaoqun C Zhou Zhou Z Dai Jin J Zhong Guangming G
Infection and immunity 20151123 2
We previously associated a missense mutation of the tc0668 gene of serial in vitro-passaged Chlamydia muridarum, a murine model of human urogenital C. trachomatis, with severely attenuated disease development in the upper genital tract of female mice. Since these mutants also contained a TC0237 Q117E missense mutation that enhances their in vitro infectivity, an effort was made here to isolate and characterize a tc0668 single mutant to determine its individual contribution to urogenital pathogen ...[more]