MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.
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ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC4731233 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.
Liu Shiyu S Liu Dawei D Chen Chider C Hamamura Kazunori K Moshaverinia Alireza A Yang Ruili R Liu Yao Y Jin Yan Y Shi Songtao S
Cell metabolism 20150910 4
Mesenchymal stem cell transplantation (MSCT) has been used to treat human diseases, but the detailed mechanisms underlying its success are not fully understood. Here we show that MSCT rescues bone marrow MSC (BMMSC) function and ameliorates osteopenia in Fas-deficient-MRL/lpr mice. Mechanistically, we show that Fas deficiency causes failure of miR-29b release, thereby elevating intracellular miR-29b levels, and downregulates DNA methyltransferase 1 (Dnmt1) expression in MRL/lpr BMMSCs. This resu ...[more]
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