Ontology highlight
ABSTRACT:
SUBMITTER: Ionita-Laza I
PROVIDER: S-EPMC4731313 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Ionita-Laza Iuliana I McCallum Kenneth K Xu Bin B Buxbaum Joseph D JD
Nature genetics 20160104 2
Over the past few years, substantial effort has been put into the functional annotation of variation in human genome sequences. Such annotations can have a critical role in identifying putatively causal variants for a disease or trait among the abundant natural variation that occurs at a locus of interest. The main challenges in using these various annotations include their large numbers and their diversity. Here we develop an unsupervised approach to integrate these different annotations into o ...[more]