Ontology highlight
ABSTRACT:
SUBMITTER: Baker Bechmann M
PROVIDER: S-EPMC4731494 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Frontiers in physiology 20160129
The goal of this study was to define Na,K-ATPase α and β subunit isoform expression and isozyme composition in colorectal cancer cells and liver metastases. The α1, α3, and β1 isoforms were the most highly expressed in tumor cells and metastases; in the plasma membrane of non-neoplastic cells and mainly in a cytoplasmic location in tumor cells. α1β1 and α3β1 isozymes found in tumor and metastatic cells exhibit the highest and lowest Na(+) affinity respectively and the highest K(+) affinity. Mese ...[more]