Unknown

Dataset Information

0

Toward precision medicine in amyotrophic lateral sclerosis.


ABSTRACT: Precision medicine is an innovative approach that uses emerging biomedical technologies to deliver optimally targeted and timed interventions, customized to the molecular drivers of an individual's disease. This approach is only just beginning to be considered for treating amyotrophic lateral sclerosis (ALS). The clinical and biological complexities of ALS have hindered development of effective therapeutic strategies. In this review we consider applying the key elements of precision medicine to ALS: phenotypic classification, comprehensive risk assessment, presymptomatic period detection, potential molecular pathways, disease model development, biomarker discovery and molecularly tailored interventions. Together, these would embody a precision medicine approach, which may provide strategies for optimal targeting and timing of efforts to prevent, stop or slow progression of ALS.

SUBMITTER: Zou ZY 

PROVIDER: S-EPMC4731596 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Toward precision medicine in amyotrophic lateral sclerosis.

Zou Zhang-Yu ZY   Liu Chang-Yun CY   Che Chun-Hui CH   Huang Hua-Pin HP  

Annals of translational medicine 20160101 2


Precision medicine is an innovative approach that uses emerging biomedical technologies to deliver optimally targeted and timed interventions, customized to the molecular drivers of an individual's disease. This approach is only just beginning to be considered for treating amyotrophic lateral sclerosis (ALS). The clinical and biological complexities of ALS have hindered development of effective therapeutic strategies. In this review we consider applying the key elements of precision medicine to  ...[more]

Similar Datasets

| S-EPMC7661549 | biostudies-literature
2012-07-25 | E-GEOD-39644 | biostudies-arrayexpress
2003-11-14 | GSE833 | GEO
2012-07-26 | GSE39644 | GEO
| S-EPMC9279904 | biostudies-literature
| S-EPMC7524331 | biostudies-literature
| S-EPMC10089700 | biostudies-literature
| S-EPMC2117704 | biostudies-literature
| S-EPMC8668313 | biostudies-literature
| S-EPMC9473725 | biostudies-literature