Ontology highlight
ABSTRACT:
SUBMITTER: Correia JC
PROVIDER: S-EPMC4731735 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Correia Jorge C JC Massart Julie J de Boer Jan Freark JF Porsmyr-Palmertz Margareta M Martínez-Redondo Vicente V Agudelo Leandro Z LZ Sinha Indranil I Meierhofer David D Ribeiro Vera V Björnholm Marie M Sauer Sascha S Dahlman-Wright Karin K Zierath Juleen R JR Groen Albert K AK Ruas Jorge L JL
Molecular metabolism 20150926 12
<h4>Objective</h4>Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known.<h4>Methods</h4>We expressed each FXR variant in primary hepatocytes and evaluated global gene expression, lipid profile, and metabolic fluxes. Gene delivery of FXR variants to Fxr(-/-) mouse liver was performed to evaluate their role in vivo. The effects of fasting a ...[more]