Ontology highlight
ABSTRACT:
SUBMITTER: Iyer S
PROVIDER: S-EPMC4731764 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Iyer Swati S Chou Fang Yu FY Wang Richard R Chiu Han Sheng HS Raju Vinay K Sundar VK Little Melissa H MH Thomas Walter G WG Piper Michael M Pennisi David J DJ
Scientific reports 20160129
The epicardium has a critical role during embryonic development, contributing epicardium-derived lineages to the heart, as well as providing regulatory and trophic signals necessary for myocardial development. Crim1 is a unique trans-membrane protein expressed by epicardial and epicardially-derived cells but its role in cardiogenesis is unknown. Using knockout mouse models, we observe that loss of Crim1 leads to congenital heart defects including epicardial defects and hypoplastic ventricular co ...[more]