Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC4731772 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Zhou Yunli Y Zhang Mi M He Dan D Hu Xueyuan X Xiong Huarong H Wu Jianyong J Zhu Biyue B Zhang Jingqing J
Scientific reports 20160129
Enzyme therapy is an effective strategy to treat diseases. Three strategies were pursued to provide the favorable microenvironments for uricase (UCU) to eventually improve its features: using the right type of buffer to constitute the liquid media where catalyze reactions take place; entrapping UCU inside the selectively permeable lipid vesicle membranes; and entrapping catalase together with UCU inside the membranes. The nanosized alkaline enzymosomes containing UCU/(UCU and catalase) (ESU/ESUC ...[more]