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New ?-glucosidase inhibitors from marine algae-derived Streptomyces sp. OUCMDZ-3434.

ABSTRACT: Wailupemycins H (1) and I (2) with a new skeleton coupled two 6-(2-phenylnaphthalene-1-yl)pyrane-2-one nuclei to a -CH2- linkage were identified from the culture of Streptomyces sp. OUCMDZ-3434 associated with the marine algae, Enteromorpha prolifera. Compounds 1 and 2 are two new ?-glucosidase inhibitors with the Ki/IC50 values of 16.8/19.7 and 6.0/8.3??M, respectively. In addition, the absolute configurations of wailupemycins D (3) and E (4) are also resolved in this paper for the first time.

SUBMITTER: Chen Z

PROVIDER: S-EPMC4731795 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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New α-glucosidase inhibitors from marine algae-derived Streptomyces sp. OUCMDZ-3434.

Chen Zhengbo Z Hao Jiejie J Wang Liping L Wang Yi Y Kong Fandong F Zhu Weiming W

Scientific reports 20160129

Wailupemycins H (1) and I (2) with a new skeleton coupled two 6-(2-phenylnaphthalene-1-yl)pyrane-2-one nuclei to a -CH2- linkage were identified from the culture of Streptomyces sp. OUCMDZ-3434 associated with the marine algae, Enteromorpha prolifera. Compounds 1 and 2 are two new α-glucosidase inhibitors with the Ki/IC50 values of 16.8/19.7 and 6.0/8.3 μM, respectively. In addition, the absolute configurations of wailupemycins D (3) and E (4) are also resolved in this paper for the first time. ...[more]

PMID: 26822662

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