Ontology highlight
ABSTRACT:
SUBMITTER: Owens NDL
PROVIDER: S-EPMC4731879 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Owens Nick D L NDL Blitz Ira L IL Lane Maura A MA Patrushev Ilya I Overton John D JD Gilchrist Michael J MJ Cho Ken W Y KWY Khokha Mustafa K MK
Cell reports 20160107 3
Transcript regulation is essential for cell function, and misregulation can lead to disease. Despite technologies to survey the transcriptome, we lack a comprehensive understanding of transcript kinetics, which limits quantitative biology. This is an acute challenge in embryonic development, where rapid changes in gene expression dictate cell fate decisions. By ultra-high-frequency sampling of Xenopus embryos and absolute normalization of sequence reads, we present smooth gene expression traject ...[more]