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SN2-Palmitate Reduces Fatty Acid Excretion in Chinese Formula-fed Infants.


ABSTRACT: Palmitic acid (PA) comprises 17% to 25% of human milk fatty acids, of which 70% to 75% are esterified to the SN2 position of the triglyceride (SN2-palmitate). In vegetable oils, which are commonly used in infant formulas, palmitate is primarily esterified to other positions, resulting in reduced calcium and fat absorption and hard stools. The aim of this study was to elucidate the effects of SN2-palmitate on nutrient excretion.In total, 171 Chinese infants were included (within 14 days of birth) in this multicenter study. Formula-fed infants were randomly assigned to receive either SN2-palmitate formula (INFAT, n?=?57) or control formula (n?=?57). The formulas (Biostime, China) differed only in their SN2 PA proportions. Stool was collected at 6 postnatal weeks.The stool dry weight and fat content of the SN2-palmitate group were lower compared with the control group (dry weight 4.25 g vs 7.28 g, P?

SUBMITTER: Bar-Yoseph F 

PROVIDER: S-EPMC4732008 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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SN2-Palmitate Reduces Fatty Acid Excretion in Chinese Formula-fed Infants.

Bar-Yoseph Fabiana F   Lifshitz Yael Y   Cohen Tzafra T   Malard Patrice P   Xu Chungdi C  

Journal of pediatric gastroenterology and nutrition 20160201 2


<h4>Objectives</h4>Palmitic acid (PA) comprises 17% to 25% of human milk fatty acids, of which 70% to 75% are esterified to the SN2 position of the triglyceride (SN2-palmitate). In vegetable oils, which are commonly used in infant formulas, palmitate is primarily esterified to other positions, resulting in reduced calcium and fat absorption and hard stools. The aim of this study was to elucidate the effects of SN2-palmitate on nutrient excretion.<h4>Methods</h4>In total, 171 Chinese infants were  ...[more]

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