Ontology highlight
ABSTRACT:
SUBMITTER: Hidaka M
PROVIDER: S-EPMC4732209 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20151202 5
Nitrate (NO3(-)) and nitrite (NO2(-)) are the physiological sources of nitric oxide (NO), a key biological messenger molecule. NO3(-)/NO2(-) exerts a beneficial impact on NO homeostasis and its related cardiovascular functions. To visualize the physiological dynamics of NO3(-)/NO2(-) for assessing the precise roles of these anions, we developed a genetically encoded intermolecular fluorescence resonance energy transfer (FRET)-based indicator, named sNOOOpy (sensor for NO3(-)/NO2(-) in physiology ...[more]