Ontology highlight
ABSTRACT:
SUBMITTER: Zou C
PROVIDER: S-EPMC4732295 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Zou Chunbin C Synan Matthew J MJ Li Jin J Xiong Sheng S Manni Michelle L ML Liu Yuan Y Chen Bill B BB Zhao Yutong Y Shiva Sruti S Tyurina Yulia Y YY Jiang Jianfei J Lee Janet S JS Das Sudipta S Ray Anuradha A Ray Prabir P Kagan Valerian E VE Mallampalli Rama K RK
Journal of cell science 20151124 1
Cardiolipin (also known as PDL6) is an indispensable lipid required for mitochondrial respiration that is generated through de novo synthesis and remodeling. Here, the cardiolipin remodeling enzyme, acyl-CoA:lysocardiolipin-acyltransferase-1 (Alcat1; SwissProt ID, Q6UWP7) is destabilized in epithelia by lipopolysaccharide (LPS) impairing mitochondrial function. Exposure to LPS selectively decreased levels of carbon 20 (C20)-containing cardiolipin molecular species, whereas the content of C18 or ...[more]