Ontology highlight
ABSTRACT:
SUBMITTER: Fouladi F
PROVIDER: S-EPMC4732463 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Fouladi Fariba F Jehn Lutz B LB Metzelder Stephan K SK Hub Florian F Henkenius Katharina K Burchert Andreas A Brendel Cornelia C Stiewe Thorsten T Neubauer Andreas A
Leukemia & lymphoma 20150303 9
Gain-of-function mutations in the RAS and FLT3 genes are frequently found in cells of acute myeloid leukemia (AML), leading to constitutive activation of signaling pathways that regulate fundamental cellular processes, and are therefore attractive targets for AML therapy. The multi-targeted kinase inhibitor sorafenib is efficacious in AML with FLT3-internal tandem duplication (ITD), but resistance to therapy is an important clinical problem. It is unclear whether AML lacking FLT3-ITD responds to ...[more]