Ontology highlight
ABSTRACT:
SUBMITTER: Payer DE
PROVIDER: S-EPMC4733157 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Payer Doris E DE Guttman Mark M Kish Stephen J SJ Tong Junchao J Adams John R JR Rusjan Pablo P Houle Sylvain S Furukawa Yoshiaki Y Wilson Alan A AA Boileau Isabelle I
Neurology 20151230 3
<h4>Objective</h4>To investigate whether levodopa-induced dyskinesias (LID) are associated with D3 overexpression in levodopa-treated humans with Parkinson disease (PD).<h4>Methods</h4>In this case-control study, we used PET with the D3-preferring radioligand [(11)C]-(+)-PHNO to estimate D2/3 receptor binding in patients with levodopa-treated PD with LID (n = 12) and without LID (n = 12), and healthy control subjects matched for age, sex, education, and mental status (n = 18).<h4>Results</h4>Com ...[more]