PVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens.
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ABSTRACT:
SUBMITTER: Hundal J
PROVIDER: S-EPMC4733280 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens.
Hundal Jasreet J Carreno Beatriz M BM Petti Allegra A AA Linette Gerald P GP Griffith Obi L OL Mardis Elaine R ER Griffith Malachi M
Genome medicine 20160129 1
Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and response to this class of therapy. Methods to identify which tumor-specific mutant peptides (neoantigens) can elicit anti-tumor T cell immunity are needed to improve predictions of checkpoint therapy response and to identify targets for vaccines and adoptive T cell therapies. Here, we present ...[more]
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