Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC4734632 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zhu Shiyao S Pabla Navjotsingh N Tang Chengyuan C He Liyu L Dong Zheng Z
Archives of toxicology 20151113 12
Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI ...[more]