ATP synthase: a molecular therapeutic drug target for antimicrobial and antitumor peptides.

ABSTRACT: In this review we discuss the role of ATP synthase as a molecular drug target for natural and synthetic antimicrobial/ antitumor peptides. We start with an introduction of the universal nature of the ATP synthase enzyme and its role as a biological nanomotor. Significant structural features required for catalytic activity and motor functions of ATP synthase are described. Relevant details regarding the presence of ATP synthase on the surface of several animal cell types, where it is associated with multiple cellular processes making it a potential drug target with respect to antimicrobial peptides and other inhibitors such as dietary polyphenols, is also reviewed. ATP synthase is known to have about twelve discrete inhibitor binding sites including peptides and other inhibitors located at

SUBMITTER: Ahmad Z 

PROVIDER: S-EPMC4734648 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature