Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad Z
PROVIDER: S-EPMC4734648 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ahmad Zulfiqar Z Okafor Florence F Azim Sofiya S Laughlin Thomas F TF
Current medicinal chemistry 20130101 15
In this review we discuss the role of ATP synthase as a molecular drug target for natural and synthetic antimicrobial/ antitumor peptides. We start with an introduction of the universal nature of the ATP synthase enzyme and its role as a biological nanomotor. Significant structural features required for catalytic activity and motor functions of ATP synthase are described. Relevant details regarding the presence of ATP synthase on the surface of several animal cell types, where it is associated w ...[more]