Ontology highlight
ABSTRACT:
SUBMITTER: Kilari D
PROVIDER: S-EPMC4734932 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kilari Deepak D Guancial Elizabeth E Kim Eric S ES
World journal of clinical oncology 20160201 1
Platinum (Pt)-based antitumor agents are effective in the treatment of many solid malignancies. However, their efficacy is limited by toxicity and drug resistance. Reduced intracellular Pt accumulation has been consistently shown to correlate with resistance in tumors. Proteins involved in copper homeostasis have been identified as Pt transporters. In particular, copper transporter receptor 1 (CTR1), the major copper influx transporter, has been shown to play a significant role in Pt resistance. ...[more]