Ontology highlight
ABSTRACT:
SUBMITTER: Ling H
PROVIDER: S-EPMC4734991 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Journal of movement disorders 20160125 1
Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson's syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribution and severity of abnormal tau accumulation and neuronal loss. In PSP subtypes, the presence of cert ...[more]