Ontology highlight
ABSTRACT:
SUBMITTER: Smock RG
PROVIDER: S-EPMC4735018 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Smock Robert G RG Yadid Itamar I Dym Orly O Clarke Jane J Tawfik Dan S DS
Cell 20160121 3
Molecular evolution has focused on the divergence of molecular functions, yet we know little about how structurally distinct protein folds emerge de novo. We characterized the evolutionary trajectories and selection forces underlying emergence of β-propeller proteins, a globular and symmetric fold group with diverse functions. The identification of short propeller-like motifs (<50 amino acids) in natural genomes indicated that they expanded via tandem duplications to form extant propellers. We p ...[more]