Ontology highlight
ABSTRACT:
SUBMITTER: Hamacher-Brady A
PROVIDER: S-EPMC4735260 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cellular and molecular life sciences : CMLS 20151126 4
Mitochondria are an essential source of ATP for cellular function, but when damaged, mitochondria generate a plethora of stress signals, which lead to cellular dysfunction and eventually programmed cell death. Thus, a major component of maintaining cellular homeostasis is the recognition and removal of dysfunctional mitochondria through autophagy-mediated degradation, i.e., mitophagy. Mitophagy further constitutes a developmental program, and undergoes a high degree of crosstalk with apoptosis. ...[more]