Ontology highlight
ABSTRACT:
SUBMITTER: Tigaret CM
PROVIDER: S-EPMC4735496 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nature communications 20160113
At glutamatergic synapses, induction of associative synaptic plasticity requires time-correlated presynaptic and postsynaptic spikes to activate postsynaptic NMDA receptors (NMDARs). The magnitudes of the ensuing Ca2+ transients within dendritic spines are thought to determine the amplitude and direction of synaptic change. In contrast, we show that at mature hippocampal Schaffer collateral synapses the magnitudes of Ca2+ transients during plasticity induction do not match this rule. Indeed, LTP ...[more]