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Inferring the Dynamics of Effective Population Size Using Autosomal Genomes.


ABSTRACT: Next-generation sequencing technology has provided a great opportunity for inferring human demographic history by investigating changes in the effective population size (Ne). In this report, we introduce a strategy for estimating Ne dynamics, allowing the exploration of large multi-locus SNP datasets. We applied this strategy to the Phase 1 Han Chinese samples from the 1000 Genomes Project. The Han Chinese population has undergone a continuous expansion since 25,000 years ago, at first slowly from about 7,300 to 9,800 (at the end of the last glacial maximum about 15,000 YBP), then more quickly to about 46,000 (at the beginning of the Neolithic about 8,000 YBP), and then even more quickly to reach a population size of about 140,000 (recently).

SUBMITTER: Hou Z 

PROVIDER: S-EPMC4735516 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Inferring the Dynamics of Effective Population Size Using Autosomal Genomes.

Hou Zheng Z   Luo Yin Y   Wang Zhisheng Z   Zheng Hong-Xiang HX   Wang Yi Y   Zhou Hang H   Wu Leqin L   Jin Li L  

Scientific reports 20160201


Next-generation sequencing technology has provided a great opportunity for inferring human demographic history by investigating changes in the effective population size (Ne). In this report, we introduce a strategy for estimating Ne dynamics, allowing the exploration of large multi-locus SNP datasets. We applied this strategy to the Phase 1 Han Chinese samples from the 1000 Genomes Project. The Han Chinese population has undergone a continuous expansion since 25,000 years ago, at first slowly fr  ...[more]

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2019-02-15 | GSE126579 | GEO