Dataset Information

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia.

ABSTRACT: Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n?=?54) and preeclamptic (n?=?18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n?=?18). Healthy non-pregnant women were also studied during their menstrual cycle (n?=?20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p?

SUBMITTER: Poveda NE

PROVIDER: S-EPMC4735521 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Publications

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia.

Poveda Natalia E NE Garcés María F MF Ruiz-Linares Carlos E CE Varón Diana D Valderrama Sergio S Sanchez Elizabeth E Castiblanco-Cortes Adriana A Agudelo-Zapata Yessica Y Sandoval-Alzate Héctor Fabio HF Leal Luis G LG Ángel-Müller Edith E Ruíz-Parra Ariel I AI González-Clavijo Angélica M AM Diéguez Carlos C Nogueiras Rubén R Caminos Jorge E JE

Scientific reports 20160201

Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the ...[more]

PMID: 26832661

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Project description:BackgroundGestational hypertension (GH) and preeclampsia (PE) are severe adverse gestational complications. Previous studies supported potential link between elevated liver enzyme levels and GH and PE. However, given the transient physiological reduction of liver enzyme levels in pregnancy, little is known whether the associations of the high-normal liver enzyme levels in early pregnancy with GH and PE exist in pregnant women.MethodsPregnant women in this study came from a sub-cohort of Shanghai Preconception Cohort, who were with four liver enzyme levels examined at 9-13 gestational weeks and without established liver diseases, hypertension and preeclampsia. After exclusion of pregnant women with clinically-abnormal liver enzyme levels in the current pregnancy, associations of liver enzyme levels, including alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT), with GH and PE status were assessed by multivariable log-binomial regression. Population attributable fraction was measured to estimate the fractions of GH and PE that were attributable to the high-normal liver enzyme levels.ResultsAmong 5,685 pregnant women 160 (2.8%) and 244 (4.3%) developed GH and PE, respectively. After adjustment for potential covariates, higher ALP, ALT and GGT levels were significantly associated with the risk of GH (adjusted risk ratio (aRR):1.21 [95% confidence interval, 1.05-1.38]; 1.21 [1.05-1.38]; and 1.23 [1.09-1.39]), as well as the risk of PE(1.21 [1.13-1.29]; 1.15 [1.03-1.28]; 1.28 [1.16-1.41]), respectively. The cumulative population attributable fraction of carrying one or more high-normal liver enzyme levels (at 80th percentile or over) was 31.4% for GH and 23.2% for PE, respectively.ConclusionHigher ALT, ALP and GGT levels within the normal range in early pregnancy are associated with increased risk of GH and PE. The documented associations provide new insight to the role of hepatobiliary function in GH and PE pathogenesis.

Dataset Information

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia.

Publications

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia.

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