Ontology highlight
ABSTRACT:
SUBMITTER: Morita D
PROVIDER: S-EPMC4735555 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Morita Daisuke D Yamamoto Yukie Y Mizutani Tatsuaki T Ishikawa Takeshi T Suzuki Juri J Igarashi Tatsuhiko T Mori Naoki N Shiina Takashi T Inoko Hidetoshi H Fujita Hiroaki H Iwai Kazuhiro K Tanaka Yoshimasa Y Mikami Bunzo B Sugita Masahiko M
Nature communications 20160113
The covalent conjugation of a 14-carbon saturated fatty acid (myristic acid) to the amino-terminal glycine residue is critical for some viral proteins to function. This protein lipidation modification, termed N-myristoylation, is targeted by host cytotoxic T lymphocytes (CTLs) that specifically recognize N-myristoylated short peptides; however, the molecular mechanisms underlying lipopeptide antigen (Ag) presentation remain elusive. Here we show that a primate major histocompatibility complex (M ...[more]